%0 Journal Article
%T Effects of Surface Characteristics on the in Vitro Biocompatibility Response of Niti Shape Memory Alloys
%A Elliot Christian Frey
%A Gabriella Sugerman
%A S£¿d£¿ka Mine Toker
%J -
%D 2019
%X Biocompatibility of three sets of Nickel-Titanium (NiTi) shape memory alloys (SMAs) with varying geometries and surface characteristics were investigated through qualitative and quantitative in vitro experiments. One set of the alloy samples used in the experiments had a plate geometry while the other two sets had cylindrical geometries with different radii. Prior to the cell culture experiments, through the structural electron microscopy and profilometer investigations, the samples were detected to exhibit different surface properties based on their geometries. With the in vitro experiments which were conducted following the structural characterization procedures, the influence of surface feature shape, distribution, and depth on the cell attachment and proliferation behaviors was investigated via electron microcopy analysis and cell count experiments. Results revealed that sample geometry and surface roughness are determining factors for initial cell attachment. However, in terms of formation of interconnected cellular networks, depth and organization of surface grooves become more critical. Overall, this study demonstrates that the biocompatibility of metallic biomaterials can be improved through the manipulation of surface properties, especially the organization and depth of surface features
%K NiTi
%K shape memory alloy
%K metallic biomaterials biocompatibility
%K surface characteristics
%K fibroblast adhesion
%U http://dergipark.org.tr/apjes/issue/40960/461169