%0 Journal Article
%T The Level of Thiol-Disulfide on Colorectal Cancer
%A Ay£¿e £¿zdemir
%J -
%D 2019
%X Aim: This study aimed to evaluate total thiol (TT), disulfide (-S-S), and native thiol (-SH) concentrations as serum biomarkers in patients with colorectal cancer (CRC). Materials and Methods: A total of 46 participants (23 patients with colorectal cancer and 23 healthy individuals) were included. Thiol/disulfide homeostasis tests (total thiol [TT], native thiol [-SH], and disulfide [-S-S]) were performed by a novel automated method. Ischemia modified albumin (IMA), albumin, carcinoembryonic antigen (CEA), carbohydrate antigen 19-9 (CA-19-9), TT, -SH, and -S-S levels as well as disulfide/native thiol and disulfide/total thiol ratios were compared between the groups. Results: In the colorectal cancer group, statistically significant difference was found in IMA, CEA, and CA-19-9, compared to the control group (p<0.05). There was no relationship between the thiol¨Cdisulfide parameters and tumor markers in the control group (p>0.05). There was no relationship between the thiol¨Cdisulfide parameters and IMA, albumin, CEA, and CA-19-9 levels in the colorectal cancer group (p>0.05). Discussion and Conclusion: Our study shows that the serum concentrations of native -SH, -S-S, and TT do not link to colorectal cancer as a noninvasive biomarker
%K biyokimyasal belirte£¿
%K tiyol dis¨¹lfit
%K kolorektal neoplazmlar
%U http://dergipark.org.tr/anadoluklin/issue/45751/469201