%0 Journal Article
%T The Relationship Between Sex and Disease Severity of Uric Acid Level in Parkinson's Disease
%A Abidin ERDAL
%J -
%D 2018
%X Parkinson's disease (PD) is a neurodegenerative disease. Oxidative stress is thought to play a role in the pathogenesis of PD. Uric acid; as an important physiological antioxidant, has been shown to be a preventive effect in the development and progression of PD. In this study, it was aimed to investigate the relationship between serum uric acid level and severity of disease in female and male patients with PD. Sixty patients followed-up with PD diagnosis were included in the study. Socio-demographic and clinical characteristics, medical treatments, serum uric acid levels, additional diseases, Unified Parkinson's Disease Rating Scale, Modified Hoehn-Yahr Scale were recorded. The relationship between sex, uric acid level, disease severity and duration was examined. Twenty-seven (45%) women and 33 (55%) men were included in the study. The mean serum uric acid level of all patients was 4.64 ¡À 1.23 mg/dl. There was no statistically significant difference between male and female PD except for uric acid levels. The uric acid level was lower in females than males (p <0.05). There was a significant negative correlation between HR and urinary acid level (p <0.05, r = -0.26) in the analysis according to the nonparametric Spearman correlation test. However, there was no statistically significant difference between male and female sex, disease severity and uric acid level . In this study, a negative correlation between the severity of illness and uric acid level was found without any difference between the sexes, and it is thought that uric acid can be used as a predictive biomarker of disease progression if it is supported by randomized large scale studies
%K Cinsiyet
%K Parkinson Hastal£¿£¿£¿
%K ¨¹rik Asit
%U http://dergipark.org.tr/muskutd/issue/40642/447917