%0 Journal Article
%T Thymoquinone exhibits anti-inflammatory, antioxidant, and immunomodulatory effects on allergic airway inflammation
%A Seyfullah Oktay Arslan
%J -
%D 2019
%X Aim: Asthma is an allergic disease causing mucus secretion, release various pro-inflammatory mediators such as tumor necrosis factor- ¦Á (TNF-¦Á) and interleukins. The aim of this study was to evaluate the effect of thymoquinone (TQ) on allergic airway inflammation in rats. Methods: Allergic airway inflammation induced by ovalbumin (OVA) challenge in sensitized-rats and effect of TQ were studied. Inflammatory cells, interleukin (IL)-6 and TNF-¦Á in bronchoalveolar lavage (BAL) fluid, and lipid peroxidation (LPO) in lung tissue were measured. Microvascular leakage was detected by Evans blue dye leakage in airway tissues. Results: Tidal volume was significantly lower in OVA group (1.4¡À 0.07 ml) than control group (1.9¡À0.04 ml) (p = 0.002), while breathing frequency was significantly higher in OVA group (135.3¡À12.9 min-1) than control group (p=0.017). In terms of tidal volume, statistical significance between TQ30 and OVA groups was found (1.8¡À0.07 ml) (p=0.008), while in terms of breathing frequency, no significance was found between both of them (126.7¡À7.3). Total white blood cell count was significantly higher in OVA group (1,376.8¡À136.4 x103/ml) than control group (545.0¡À106.7 x103/ml) (p<0.001). Statistical significance was found in TQ10 (824.7¡À4.5 x103/ml) group when compared OVA group (p=0.036), while statistical significance was not found in TQ1 group (1,282.2¡À137.7 x103/ml). When compared OVA group (60.3¡À4.9 pg/ml) with control group in terms of the TNF-¦Á level, statistical significance was found (36.7¡À 4.7 pg/ml) (p=0.011). The Evans blue dye level was significantly higher in OVA group (31.8¡À3.6 ng/mg of tissue) than control (12.5¡À1.1 ng/mg of tissue) group (p<0.001), and TQ10 group (16.3¡À6.7 ng/mg of tissue) (p=0.002), and TQ30 (13.5¡À1.0 ng/mg of tissue) group (p<0.001). Conclusion: These findings reveal that TQ could be beneficial in asthma pathophysiology due to its immunomodulatory, anti-inflammatory, and antioxidant effects
%K TNF-¦Á
%K Alerjik solunum yolu enflamasyonu
%K mikrovask¨¹ler s£¿z£¿nt£¿
%K ovalbumin
%K timokinon
%U http://dergipark.org.tr/acem/issue/47515/527359