%0 Journal Article
%T In Patients With Necrotizing Enterocolitis; Relationship of IgA, IgG, PAF, IL-8 and IL-10 Levels with Clinic
%J -
%D 2019
%X Abstract Necrotizing enterocolitis (NEC) is the most common gastrointestinal emergency in preterm neonates. Modernintensi ve care units and newborn care contributed towardsincreased survival of the neonates over last few decades. But the incidence and long term health problems in NEC is unchanged due to lack of systematic preventive strategy. The pathophysiology of NEC is multifactorial andnot precisely defined. However, it is related to immature innate immunity of newborn intestine and exaggerated inflammatory response. The aim of our study was to determine PAF, IL-8, IL-10 and IgA, IgG levels and clinical roles of these inflam-matory cytokines in NEC patients. Method: Patients with necrotizing enterocolitis are divided into 3 groups according to Bell`s classification. Firstgroup included 12 newborn infants with NEC I (suspec-ted NEC). Second group included 11 newborn infants with NEC II (proven NEC). 3rd group included 13 newborninfants NEC III (advanced NEC), The 4th group (controlgroup) 17 newborn healthy. PAF, IL-8, IL-10, IgA ve IgG tests were carried out by the ELISA method in the ELISYSU no-Human full-automatic analyzer at the Immunological Laboratory Division of the Clinical Diagnostic Laboratory Department of the Scientific Research Institute. The measurement data were presented as mean ¡À SD, and repeated measurement data were compared among the groups. p<0.05 was considered statistically significant. Results:Serum PAF, IL-8 and IL-10 levels were significantly higher in NEC group than in control group (p<0.001). When the immunoglobulin levels were compared statistically, serum IgA level was significantly higher in the NEC group compared to the control group(p<0.001), while serum IgG levels were significantly higher in the control group than in all NEC groups (p<0.05). No significant difference was found between IL-10 levelsand serum PAF, IL-8, IgG and IgA levels of NEK-1, NEK-2 and NEK-3 groups. Conclusion: When there is no equilibrium between proinflammatory and anti-inflammatory mediators in premature babies, development of NEC is easier and moresevere. In our study, it was determined that serum PAF,IL-8, IL-10 and IgA levels were significantly higher inpatients with NEC compared to the control group, IgG levels were lower, and these were correlated with the clinic. Further studies are needed to use these markers in the diagnosis and clinical follow-up of NEC
%K Nekrotizan enterokolit
%K IL-8
%K IL-10
%K PAF
%U http://dergipark.org.tr/ktpd/issue/47815/602751