%0 Journal Article
%T Evaluation of Febrile Neutropenic Episodes of Childhood Malignancies
%A Ahu Aksay
%A Dilek G¨¹ne£¿ £¿nce
%A Ersin T£¿ret
%A Muhammet Bulut
%A Tuba Hilkay Karap£¿nar
%A Ye£¿im Oymak
%A Y£¿lmaz Ay
%A £¿lker Devrim
%J -
%D 2019
%X Introduction:The most important side effect of therapeutics given for cancer treatment is febrile neutropenia. Neutropenia expected to be longer than seven days and severe neutropenia (absolute neutrophil count <100/mm3) especially in hematologic cancers and solid organ tumors that show bone marrow dissemination is accepted as a high-risk feature by American Infectious Disease Society. The emergent approach to a febrile neutropenia attack is to give intravascular antibiotherapy within the shortest time possible. We aimed to evaluate the febrile neutropenia attacks of pediatric cancer patients in a tertiary referral hospital during a 27-month period. Methods:Febrile neutropenia attacks of cases treated between January 2012 and March 2014 were investigated retrospectively from the patient files. Febrile neutropenia was defined as absolute neutrophil count below 500/mm3 or between 500-1000/ mm3 but expected to fall below 500/mm3 within 48 hours in the presence of fever of 38,50C with single axillary measurement or above 380C for one hour or two measurements above 380C within 4 hours. Results:One hundred thirty-one febrile neutropenia attacks of 48 patients were investigated retrospectively. Fever was managed within 24 hours in 69% patients. Peripheral and catheter-drawn blood cultures showed bacterial growth in 36% of the attacks, 64% of these growths being gram negative bacteria. Empirical treatment with piperacilin-taxobactam was observed to be efficient in 32% of the attacks. As a supportive treatment, cases received G-CSF in 19% of the attacks. Conclusion:In order to, minimize morbidity and mortality of febrile neutropenia, wide spectrum antibiotics must be given intravenously within the shortest time possible in pediatric cancers
%K £¿ocukluk £¿a£¿£¿
%K febril n£¿tropeni
%K kanser
%K l£¿semi
%U http://dergipark.org.tr/mkutfd/issue/44115/489213