%0 Journal Article
%T Analysis of Autoimmune Diseases-Human Gut Microbiota Association Using Transcriptome Data and Omic Tools
%A Tuba SEV£¿MO£¿LU
%J -
%D 2019
%X Recent advances in omic analyses and the accurate determination of DNA sequencing of genomes of human-related microbial communities have helped increase the knowledge of the function and structure of human microbiota in diseased and healthy states. However there is still not much work done in this regard. In this study, three important autoimmune diseases, Psoriasis, Rheumatoid Arthritis and Atopic Dermatitis were selected. Firstly the transcriptional regulation for these diseases were integrated with metabolic pathways using omic tools. Secondly the link between human intestinal microbial species and these diseases were revealed. The results have shown that there is a mutual group of microbial species among the selected diseases. These are intensively species of Firmicutes, Deltaproteobacteria, Bacteriodetes and Actinobacteria phyla. Another noteworthy aspect of this study is that the microbial species of the Tenericutes phyla are intensely present in atopic dermatitis and rheumatoid arthritis but not in psoriasis. These results display that human gut microbiota has a role in complex autoimmune diseases. This study showed that not only genes and proteins, but also metabolites, microbiota and pathogen groups should be examined and analyzed in detail in order to comprehend the mechanism of a disease
%K Otoimm¨¹nite
%K Psoriazis
%K Atopik Dermatit
%K Romatoid Artrit
%K Metabolit
%K £¿nsan Ba£¿£¿rsak Mikrobiyatas£¿
%U http://dergipark.org.tr/sdufenbed/issue/39838/449136