%0 Journal Article
%T The Relationship Between Toll-Like Receptor 2 Mutation And IL-1 Receptor Antagonist Polymorphism With Tuberculosis Disease
%A Seda Tural £¿n¨¹r
%J -
%D 2018
%X Background: Toll-like receptor 2 (TLR-2) plays role in the immune response of mycobacteria. Interleukin-1(IL-1) is a cytokine that plays a role in T cell activation and effect with TNF. Interleukin-1 receptor antagonist(IL-1RA) is a natural inhibitor of IL-1. The aim of this study was to demonstrate the relationship between tuberculosis and Arg753Gln mutation in the TLR-2 gene and the effect of IL-1RA polymorphism, which is claimed to increase the susceptibility to tuberculosis in several studies. Materials and Methods: We compared mutation analysis of 119 consecutive patients with active tuberculosis or tuberculous pleurisy and 83 ethnically matched healthy volunteers. Results: GG frequency was 97.48 % and GA frequency was 2.52% in the tuberculosis group. We found no statistically significant risk for the GA genotype and IL-1RA alleles. Allele-2 polymorphism correlation with reduced delayed-type hypersensitivity response to PPD (Purified protein derivative) was not statistically significant in our series (p=0.084). Conclusion: The results of this study do not support the hypothesis that claims that there is a relationship between Arg753Gln mutation and the risk of developing tuberculosis. The results of the present study do not support the presence of a relationship between IL-1RA polymorphism and the development and course of tuberculosis
%K TOLL-LIKE RECEPTOR 2
%K IL-1 RECEPTOR ANTAGONIST
%K TUBERCULOSIS
%U http://dergipark.org.tr/eutd/issue/39026/435590