%0 Journal Article
%T The evaluation of neutrophil/lymphocyte ratio in Parkinson's disease
%J -
%D 2019
%X Purpose: Parkinson's Disease is a neurodegenerative disease that is thought to play a role in the pathogenesis of chronic inflammation. Neutrophil/lymphocyte ratio is a marker of peripheral inflammation. In this study, it was aimed to investigate the relationship between neutrophil/lymphocyte ratio and the stage, duration, and subtypes of Parkinson disease. Materials and methods: Ninety patients diagnosed according to the criteria of the United Kingdom Parkinson's Disease Society Brain Bank were retrospectively evaluated demographically. The drugs they were using, the presence of non-motor symptoms, the Unified Parkinson's Disease Rating Scale, the Modified Hoehn-Yahr Scale and neutrophil/lymphocyte ratio were recorded and the relationship between them was investigated. Results: The mean age of the 90 patients included in the study was 67.31¡À9.2 years. 33.3% of the patients were female (n=30) and 66.7% were male (n=60). The mean duration of disease was 6.91¡À5.06 years. The mean Unified Parkinson's Disease Rating Scale was 22.2¡À11.6, Modified Hoehn-Yahr Scale was 2.64¡À0.88. 56.7% of the patients were akinetic-rigid, while 43.3% were tremor-dominant. Non - motor symptoms of the patients were constipation in 57.8%, depression in 33.3%, anosmia in 41.1% and REM sleep behavior disorder in 57.8%. 61.1% of patients were using L-dopa and dopamine agonist, 18.9% were only dopamine agonists, 17.8% were using only L-dopa and 2.2% were using only MAO-B inhibitor. The mean number of neutrophils (4.54¡À1.01)x103, mean lymphocyte number is (1.97¡À0.60)x103 and neutrophil / lymphocyte ratio of the patients were 2.47¡À0.82. Conclusion: There were no statistically significant difference between neutrophil / lymphocyte ratio and subtypes of Parkinson's Disease, gender, Modified Hoehn-Yahr Scale and duration of Parkinson's Disease. There is a need for further work in Parkinson's Disease that requires further evidence for the role of peripheral inflammation in the development of neurodegeneration
%K Parkinson hastal£¿£¿£¿
%K n£¿trofil/lenfosit oran£¿
%K enflamasyon
%U http://dergipark.org.tr/patd/issue/45448/501925