%0 Journal Article
%T Effects of VDBP and VDR Mutations and Other Factors to the Development of Stent Thrombosis in Coronary Artery Disease Patients
%A Deniz K£¿ra£¿
%J -
%D 2018
%X Objective: This study aimed to investigate the relationship between genetic and environmental factors that are believed to have an effect on stent thrombosis (ST) in coronary artery disease (CAD) patients after stent implantation. Methods: Seventy-three CAD patients who were implanted with stents by surgical intervention were enrolled. Thirty-seven patients with ST were included in the patient group, and 36 patients without ST were included in the control group. After obtaining necessary information from the patients, DNA was isolated from blood. Rs2228570 and rs1544410 mutations in the vitamin D receptor (VDR) gene as well as rs4588 and rs7041 mutations in the vitamin D-binding protein (VDBP) gene were investigated by performing real-time polymerase chain reaction. Biochemical measurements, such as those of vitamin D and lipid levels, were performed using appropriate kits. Results were evaluated using statistical methods. Results: The number of individuals who carry homozygous or heterozygous alleles of the rs4588 mutation in the VDBP gene was found to be statistically high in the patient group (p=0.027). Vitamin D and hemoglobin levels were significantly low and C-reactive protein levels were significantly high, while the occurrence of vitamin D deficiency, hypertension, and familial history of CAD as well as the current status of smoking were significantly high in the patient group (p<0.05). Additionally, the presence of a homozygous rs1544410 mutation in the VDR gene of individuals who have diabetes mellitus was statistically high (p=0.035). According to genotype distribution, statistical significance was observed between hemoglobin A1c (HbA1c) levels and the rs1544410 mutation (p<0.05). Conclusion: The rs4588 mutation, which plays a role in vitamin D metabolism, vitamin D deficiency, and some other risks, in the VDBP gene may cause ST
%K Koroner arter hastal£¿£¿£¿
%K stent trombozu
%K vitamin D resept£¿r geni
%K vitamin D ba£¿lay£¿c£¿ protein geni
%U http://dergipark.org.tr/marusbed/issue/39105/464184