%0 Journal Article
%T Serum hepcidin levels in active and inactive Behcet¡¯s disease
%A Mustafa £¿ahin
%J -
%D 2019
%X Aim: This study aims to evaluate the alteration of hepcidin synthesis in response to inflammation and to reveal the relationship between hepcidin and acute phase reactants in Behcet¡¯s disease (BD) which is also an inflammatory disease. Material and Methods: That was included 52 BD patients (15 with active, 37 with inactive disease), 13 isolated iron deficiency anemia patients and 13 healthy controls; totally 78 individuals to the study. Patients with chronic disease anemia had 3 active and 1 inactive Behcet's disease. Levels of bioactive hepcidin-25 were measured by ELISA method. Result: Low hepcidin levels were found significantly in inactive BD and the main BD groups comparing to healthy controls (p=0.015, p=0.014, respectively); in BD with anemia of chronic disease group comparing to healthy controls and isolated iron deficiency anemia group (p=0.007, p=0.003, respectively). Besides it was not found any significant difference between hepcidin levels of active BD group and healthy controls (p>0.05). Conclusion: Contrary to its increment pattern in inflammation, increased hepcidin levels in Behcet¡¯s patients were not detected. Alternation of serum Interleukin-6 (IL-6) levels with anti-inflammatory treatments affecting hepcidin levels necessitate hepcidin measurement only in Behcet¡¯s patients who have been recently diagnosed and/or haven't received a treatment before and evaluation of the measurement together with IL-6 levels
%K Beh£¿et hastal£¿£¿£¿
%K kronik hastal£¿k anemisi
%K hepsidin
%U http://dergipark.org.tr/ortadogutipdergisi/issue/44313/413997