%0 Journal Article
%T The role of the neutrophil-to-lymphocyte ratio in predicting acute kidney injury in patients with acute pancreatitis
%A Zeynep B£¿y£¿k
%J -
%D 2019
%X Background and Aims: Neutrophil-to-lymphocyte ratio is an inflammatory marker that has been demonstrated to predict the development of acute kidney injury in various diseases. We investigated the role of the neutrophil-to-lymphocyte ratio in predicting acute kidney injury in patients with acute pancreatitis. Materials and Method: A total of 186 patients diagnosed with acute pancreatitis in Selcuk University School of Medicine [A1] between September 2016 and September 2018 were included in this retrospective study. The diagnosis and severity of acute pancreatitis were defined according to the revised Atlanta classification, while the KDIGO criteria were used for the diagnosis and staging of acute kidney injury. We also collected details pertaining to laboratory values and prognostic scoring systems of the patients obtained at their first visit to the emergency service. Results: Of the 186 patients, more than half were females (59.7%), and the average age of the patients was 59.3¡À17.3 years. Acute kidney injury was detected in 26.3% of the patients, who were found to be older and more hypertensive than patients without acute kidney injury (p=0.001 for both). The duration of hospitalization and the duration of intensive care unit stay of patients with acute kidney injury were significantly longer (p=0.001 for both). White blood cell and neutrophil counts were significantly higher in the acute kidney injury group, whereas the lymphocyte count was significantly lower (p <0.001 for all three). The neutrophil-to-lymphocyte ratio and C-reactive protein levels measured during patient admission were significantly higher in the acute kidney injury group (p <0.001 for both). Hematocrit, thrombocyte, and red cell distribution width values were similar in both groups (p >0.05). The multivariate regression analysis showed that age (OR: 0.964, 95% [A2] CI: 0.925-1.004, p=0.008), neutrophil-to-lymphocyte ratio (OR: 1.096, 95% CI: 1.028-1.170, p=0.005), and BISAP score (OR: 6.582, 95% CI: 2.810-15.414, p <0.001) were independent predictors of acute kidney injury for determining the factors that could independently predict the development of acute kidney injury in patients with acute pancreatitis. The receiver operating characteristic curve revealed an area under curve of 0.813 (95% CI: 0.742¨C0.883), a sensitivity of 73.4%, and a specificity of 81.4% for a cut-off neutrophil-to-lymphocyte ratio value of 11.2. Conclusions: Baseline neutrophil-to-lymphocyte ratio evaluated during patient admission may be a useful predictor of acute kidney injury in patients with acute
%K Akut pankreatit
%K n£¿trofil lenfosit oran£¿
%K akut b£¿brek hasar£¿
%U http://dergipark.org.tr/agd/issue/45511/548747