%0 Journal Article
%T Prospect of Natural Killer Cells in Cancer Imunotherapy
%A Andi Wijaya
%A Anna Meiliana
%A Nurrani Mustika Dewi
%J -
%D 2018
%R https://doi.org/10.18585/inabj.v10i3.532
%X BACKGROUND: Current understanding in molecular character of natural killer (NK) cell, its function and mechanisms, send people the ideas to develop a NK cell-based immunotherapeutic strategies against human cancer. CONTENT: Before being regards as a cell-based cellular therapy, NK cell have to be clinical proven. Early studies with NK cells infusions for acute myeloid leukemia and lung cancer showed a promising result. NK cells need simplified methods for enriching and expanding, in addition to its transfection with chimeric antigen receptors (CARs). NK-92 arise as an assuring effector cells to augment monoclonal and bispecific antibody therapy. Thus, NK cells show a potential opportunity for cell engineering, outstep the era of T cells. SUMMARY: It is believed that NK cells bring a bright hope for future cancer immunotherapies, either alone or in combination as a harmonious therapy. KEYWORDS: NK cells, NK-92 cells, immunotherapy, CA
%K NK cells
%K NK-92 cells
%K immunotherapy
%K CAR
%U https://inabj.org/index.php/ibj/article/view/532