%0 Journal Article
%T Overexpression of p53 in extra large (more than 10 cm) hepatocellular carcinoma
%A Marini Stephanie
%A Nurjati C. Siregar
%A Toar J.M. Lalisang
%A Yefta Moenadjat
%J -
%D 2018
%R https://doi.org/10.13181/mji.v27i2.1980
%X Background: Extra large hepatocellular carcinoma (HCC) of >10 cm managed in our center shows a specific characteristic in tropical regions. This type of HCC exhibits distinct p53 expression. This study aimed to determine the association between p53 expression and tumor size and behavior. Method: Subjects with HCC who underwent surgical resection in our hospital during 2012¨C2015 were enrolled in this study. Subject¡¯s characteristics, tumor size, histopathology findings, and tumor behavior were variables observed. An immunohistochemical study on p53 expression was conducted to determine its association with those variables. Results: This study involved 38 subjects with tumor size ranging from 3 cm to 25 cm in diameter and 20 subjects (52.8%) with tumor size ranging from 10 cm to 25 cm in diameter. Only 13 samples were evaluated for p53 expression. Five subjects with >10 cm (extra large) tumor showed highly/overexpressed p53 (intensity>50%), two subjects with strong p53 expression (intensity>5%¨C50%), and two subjects with weak expression. Three subjects with <10 cm (large) tumor showed strong expression of p53 (5%¨C9%) and a subject with 3 cm tumor showed weak p53 expression (<5%). Highly expressed p53 was found in patients with microvascular invasion, inflammatory response, mitosis, and necrosis. Conclusion: Overexpression of p53 was associated with extra large and poorly differentiated HCC
%K HCC
%K p53
%K poorly differentiated tumor
%K tumor size
%U http://mji.ui.ac.id/journal/index.php/mji/article/view/1980