%0 Journal Article
%T Copper-Catalyzed Asymmetric Aminocyanation of Arylcyclopropanes for Synthesis of ¦Ã-Amino Nitriles
%J -
%D 2019
%R https://doi.org/10.1021/acscatal.8b03768
%X A facile approach for the synthesis of enantiopure ¦Ã-amino nitriles by copper-catalyzed aminocyanation of arylcyclopropanes is disclosed, which undergoes the highly enantioselective ring-opening reaction of cyclopropanes. The strategy utilizes N-fluorobenzenesulfonimide as nucleophilic nitrogen source as well as oxidant and trimethylsilyl cyanide as the other nucleophile, and it probably operates via a key radical cation intermediate. This reaction provides an efficient platform for asymmetric 1,3-difunctionalization of cyclopropanes
%U https://pubs.acs.org/doi/10.1021/acscatal.8b03768