%0 Journal Article
%T Synthesis of gem-Difluoroalkenes via Nickel-Catalyzed Reductive C¨CF and C¨CO Bond Cleavage
%J -
%D 2019
%R https://doi.org/10.1021/acscatal.8b04348
%X By merging C¨CO and C¨CF bond cleavage in cross-electrophile coupling, we developed a method for efficient synthesis of gem-difluoroalkenes with an alkoxy-substituent on the homoallylic position using easily accessible acetals as coupling partners with ¦Á-trifluoromethyl alkenes. Remarkably, this Ni-catalyzed allylic defluorinative cross-coupling reaction demonstrates high tolerance of a wide range of sensitive functional groups and proves to be applicable in late-stage functionalization of structurally complex compounds
%U https://pubs.acs.org/doi/10.1021/acscatal.8b04348