%0 Journal Article
%T Polymer Amphiphiles for Photoregulated Anticancer Drug Delivery
%J -
%D 2019
%R https://doi.org/10.1021/acsami.8b18099
%X We report the synthesis of amphiphilic polymers featuring lipophilic stearyl chains and hydrophilic poly(ethylene glycol) polymers that are connected through singlet oxygen-cleavable alkoxyanthracene linkers. These amphiphilic polymers assembled in water to form micelles with diameters of ¡«20 nm. Reaction of the alkoxyanthracene linkers with light and O2 cleaved the ether C¨CO bonds, resulting in formation of the corresponding 9,10-anthraquinone derivatives and concomitant disruption of the micelles. These micelles were loaded with the chemotherapeutic agent doxorubicin, which was efficiently released upon photo-oxidation. The drug-loaded reactive micelles were effective at killing cancer cells in vitro upon irradiation at 365 nm, functioning through both doxorubicin release and photodynamic mechanisms
%U https://pubs.acs.org/doi/10.1021/acsami.8b18099