%0 Journal Article
%T Conversion of Aldoses to Valuable ¦Ø-Amino Alcohols Using Amine Transaminase Biocatalysts
%J -
%D 2019
%R https://doi.org/10.1021/acscatal.8b04564
%X The conversion of readily available monosaccharides to high-value amino alcohols using a key biocatalytic step is an attractive strategy for the preparation of these chiral synthons. Here, we report a previously undescribed example of the direct amination of monosaccharides, which exist predominantly in their cyclic form at equilibrium, using amine transaminase biocatalysts, providing access to a panel of amino alcohols in moderate to high conversion and isolated yield. A recently developed high-throughput colorimetric screen, employing o-xylylenediamine, was initially used to identify amine transaminase enzymes displaying this activity toward cyclic sugars, and reactions were successfully scaled up using isopropylamine
%U https://pubs.acs.org/doi/10.1021/acscatal.8b04564