%0 Journal Article
%T Advance of Seriniquinone Analogues as Melanoma Agents
%J -
%D 2019
%R https://doi.org/10.1021/acsmedchemlett.8b00391
%X Seriniquinone, a marine natural product, displayed potent cytotoxicity and selectivity against melanoma cancer cells. This selectivity, combined with a novel mode of action (MOA), prompted studies to translate a pharmacologically relevant lead. Herein, we report on structure¨Cactivity relationships (SARs), and provide a strategy to prepare analogues that retain activity and offer an improved water solubility and isomeric purity. From intermediates made on a gram-scale, derivatives were prepared and evaluated for their antiproliferation activity and melanoma selectivity. Overall these studies provide methods to install side chain motifs that demonstrate a common, and yet unique, biological profile
%U https://pubs.acs.org/doi/10.1021/acsmedchemlett.8b00391