%0 Journal Article
%T Self-assembling Releasable Thiocolchicine¨CDiphenylbutenylaniline Conjugates
%J -
%D 2019
%R https://doi.org/10.1021/acsmedchemlett.8b00605
%X The design and the synthesis of new self-assembling conjugates is reported. The target compounds are characterized by the presence of a self-immolative linker that secures a controlled release induced by lipase cleavage. 4-(1,2-Diphenylbut-1-en-1-yl)aniline is used as a self-assembling inducer and amino-thiocolchicine as prototype of drug. The release of thiocolchicine derivative has been demonstrated in vitro in the presence of porcine pancreatic lipase and Celite-supported lipase. The formation of nanoparticles is confirmed by dynamic light scattering, atomic force microscopy, and fluorescence microscopy. The antiproliferative activity has been proved on two human cancer cell lines
%U https://pubs.acs.org/doi/10.1021/acsmedchemlett.8b00605