%0 Journal Article
%T Identification of Human Toll-like Receptor 2-Agonistic Activity in Dihydropyridine¨CQuinolone Carboxamides
%J -
%D 2019
%R https://doi.org/10.1021/acsmedchemlett.8b00540
%X Using a multiplexed, reporter gene-based, high-throughput screen, we identified 9-fluoro-7-hydroxy-3-methyl-5-oxo-N-(pyridin-3-ylmethyl)-2,3-dihydro-1H,5H-pyrido[3,2,1-ij]quinoline-6-carboxamide as a TLR2 agonist. Preliminary structure¨Cactivity relationship studies on the carboxamide moiety led to the identification of analogues that induce chemokines and cytokines in a TLR2-dependent manner. These results represent new leads for the development of vaccine adjuvants
%U https://pubs.acs.org/doi/10.1021/acsmedchemlett.8b00540