%0 Journal Article %T Chalcones and Chalcone-mimetic Derivatives as Notch Inhibitors in a Model of T-cell Acute Lymphoblastic Leukemia %J - %D 2019 %R https://doi.org/10.1021/acsmedchemlett.8b00608 %X Based on hit-likeness and chemical diversity, a number of chalcones and chalcone-mimetic compounds were selected as putative Notch inhibitors. The evaluation of the antiproliferative effect combined with the inhibition of Notch1 expression in KOPTK1 cell line identified compound 18, featuring a tetrahydronaphthalene-based scaffold, as a new promising Notch-blocking agent %U https://pubs.acs.org/doi/10.1021/acsmedchemlett.8b00608