%0 Journal Article
%T Multi-Omics Strategies Uncover Host¨CPathogen Interactions
%J -
%D 2019
%R https://doi.org/10.1021/acsinfecdis.9b00080
%X With the success of the Human Genome Project, large-scale systemic projects became a reality that enabled rapid development of the systems biology field. Systems biology approaches to host¨Cpathogen interactions have been instrumental in the discovery of some specifics of Gram-negative bacterial recognition, host signal transduction, and immune tolerance. However, further research, particularly using multi-omics approaches, is essential to untangle the genetic, immunologic, (post)transcriptional, (post)translational, and metabolic mechanisms underlying progression from infection to clearance of microbes. The key to understanding host¨Cpathogen interactions lies in acquiring, analyzing, and modeling multimodal data obtained through integrative multi-omics experiments. In this article, we will discuss how multi-omics analyses are adding to our understanding of the molecular basis of host¨Cpathogen interactions and systemic maladaptive immune response of the host to microbes and microbial products
%U https://pubs.acs.org/doi/10.1021/acsinfecdis.9b00080