%0 Journal Article
%T Multicomponent Approach to a Library of N-Substituted ¦Ã-Lactams
%J -
%D 2019
%R https://doi.org/10.1021/acscombsci.8b00147
%X The ¦Ã-lactam motif is often found in naturally occurring compounds with diverse biological activities. We prepared a 28-member library of N-substituted ¦Ã-lactams following a single-pot, three-component Ugi reaction comprising bifunctional building block, l-glutamic acid methyl ester. The reaction tolerates structurally diverse carbonyl and isocyanide components providing a robust access to functionalized ¦Ã-lactams. Antimicrobial susceptibility testing, including agar well diffusion assay, serial microdilution broth assay, and antibiofilm activity testing, identified a potent compound with antibiofilm activity against Staphylococcus aureus ATCC 6538
%U https://pubs.acs.org/doi/10.1021/acscombsci.8b00147