%0 Journal Article %T Synthesis of a 6-Aza-Isoindolinone-Based Inhibitor of Phosphoinositide 3-Kinase ¦Ã via Ruthenium-Catalyzed [2 + 2 + 2] Cyclotrimerization %J - %D 2019 %R https://doi.org/10.1021/acsmedchemlett.8b00530 %X Phosphoinositide 3-kinase (PI3K¦Ã) is a drug target that has been implicated in the treatment of a range of diseases. We have developed a synthesis of a novel PI3K¦Ã inhibitor containing a 1,2-dihydro-3H-pyrrolo[3,4-c]pyridin-3-one scaffold. The key step in the synthesis involved a ruthenium-catalyzed [2 + 2 + 2] cyclotrimerization reaction between a diyne and an alkoxycarbonyl isocyanate, a previously unreported coupling partner in such a reaction %U https://pubs.acs.org/doi/10.1021/acsmedchemlett.8b00530