%0 Journal Article
%T Covalent Inhibitors of Plasmodium falciparum Glyceraldehyde 3-Phosphate Dehydrogenase with Antimalarial Activity in Vitro
%J -
%D 2019
%R https://doi.org/10.1021/acsmedchemlett.8b00592
%X Covalent inhibitors of PfGAPDH characterized by a 3-bromoisoxazoline warhead were developed, and their mode of interaction with the target enzyme was interpreted by means of molecular modeling studies: some of them displayed a submicromolar antiplasmodial activity against both chloroquine sensitive and resistant strains of Plasmodium falciparum, with good selectivity indices
%U https://pubs.acs.org/doi/10.1021/acsmedchemlett.8b00592