%0 Journal Article
%T Glial-Neuron Transformation by ˇ°Chemical Cocktailˇ±
%J -
%D 2019
%R https://doi.org/10.1021/acschemneuro.8b00684
%X High Resolution Image Download MS PowerPoint Slide Repairing of brain damage is a challenging task due to the limited regenerative potential of complex network of neurons interspersed with glial cells. To address this issue, a number of approaches are in progress. Here we discuss a fascinating approach in which reactive astrocytes generated during any brain injury can be transformed into functional neurons using a mixture of small molecules or ˇ°chemical cocktailˇ±. This ˇ°chemical cocktailˇ± leads to the conversion of reactive astrocytes into neurons by targeting two very important transcription factors, NeuroD1 and NeuroG2. This chemical approach opens up a new direction in development of regenerative medicine
%U https://pubs.acs.org/doi/10.1021/acschemneuro.8b00684