%0 Journal Article
%T Interaction of ¦Á-Synuclein with ATP Synthase: Switching Role from Physiological to Pathological
%J -
%D 2019
%R https://doi.org/10.1021/acschemneuro.8b00407
%X The most abundantly present protein found in Lewy bodies, which is the pathological hallmark of Parkinson¡¯s disease, is ¦Á-synuclein. Native monomeric ¦Á-synuclein is localized within mitochondria, interacts with ATP synthase subunit, and enhances ATP synthase efficiency and mitochondrial function. Recently, an advanced study shows that the interaction of ¦Á-synuclein oligomer with ATP synthase switches its role from physiological to pathological, which leads to mitochondrial dysfunction
%U https://pubs.acs.org/doi/10.1021/acschemneuro.8b00407