%0 Journal Article
%T Combinatorial Library of Light-Cleavable Lipidoid Nanoparticles for Intracellular Drug Delivery
%J -
%D 2019
%R https://doi.org/10.1021/acsbiomaterials.9b00445
%X Synthetic lipid-like molecules (lipidoids) are superior for intracellular delivery of various bioactive cargos. Through incorporating stimuli-responsive linkers, lipidoid nanoparticle-based delivery systems with triggered-release features can be constructed. Enhanced delivery performances have been achieved using disulfide bond-containing bioreducible lipidoids. Herein, we further expand the stimuli-responsive combinatorial lipidoids library by integrating the photocleavable o-nitrobenzyl moiety into the hydrophobic tail of the lipidoids. The structures of these novel lipidoids were confirmed by NMR and MS. The nanoparticles were fabricated through self-assembly procedures, and their photoresponsive behaviors were examined. Light-regulated cargo release and following functionality restoration indicated the potential of the newly developed lipidoid nanoparticles for spatiotemporal delivery
%U https://pubs.acs.org/doi/10.1021/acsbiomaterials.9b00445