%0 Journal Article
%T Amantadine Surface-Modified Silver Nanorods Improves Immunotherapy of HIV Vaccine Against HIV-Infected Cells
%J -
%D 2018
%R https://doi.org/10.1021/acsami.8b10948
%X Surface modifications can endow nanomaterials with presupposed immunoregulatory functions to optimize vaccine-induced immune responses. In this work, we modified an immunoregulatory molecule, amantadine (Ada), on the outermost layer of PVP¨CPEG-coated silver nanorods (Ada¨CPVP¨CPEG silver nanorods). Such Ada surface-modified silver nanorods promote HIV vaccine-triggered cytotoxic lymphocytes (CTLs) to produce around eightfold stronger tumor necrosis factor alpha (TNF-¦Á) in vivo. The enhancement of HIV-specific CTL-derived TNF-¦Á significantly facilitates the death of HIV-infected cells (from 28.86 to 84.19%) and reduces HIV production (around sixfold). This work supports the critical role of surface modifications of nanomaterials in fundamentally improving the immunotherapy of HIV vaccine against HIV-infected cells
%U https://pubs.acs.org/doi/10.1021/acsami.8b10948