%0 Journal Article
%T Easy-to-Use Colorimetric Cyanine Probe for the Detection of Cu2+ in Wilson¡¯s Disease
%J -
%D 2018
%R https://doi.org/10.1021/acsami.8b07081
%X Copper(II) is one of the essential metal elements in human body, which can accumulate in many organs and finally excrete in urine. Excessive load of Cu2+ can cause liver cirrhosis, kidney dysfunction, and many neurological symptoms in the case of Wilson¡¯s disease (WD). Therefore, the selective and efficient detection of Cu2+ is of great importance. Although various fluorescent probes have been reported for the detection of Cu2+, an efficient and capable probe is still rare for patients¡¯ self-use on a routine basis. In this study, we developed an easy-to-use probe CY1 based on UV¨Cvis¨Cnear-infrared absorption changes with excellent sensitivity and selectivity for Cu2+. The mechanism of oxidation of CY1 by Cu2+ was first explored. We demonstrated the role of the probe in the quantitative detection of Cu2+ in urine from WD patients and showed that it has great potential for clinical applications
%U https://pubs.acs.org/doi/10.1021/acsami.8b07081