%0 Journal Article
%T Hydrogen Atom Transfer (HAT)-Triggered Iron-Catalyzed Intra- and Intermolecular Coupling of Alkenes with Hydrazones: Access to Complex Amines
%J -
%D 2018
%R https://doi.org/10.1021/acscatal.8b03794
%X A methodology for the coupling of alkenes with aldehyde- or ketone-derived Cbz-hydrazones to form a new C¨CC bond through a radical process is described. The sequence comprises an initial in situ generation of a putative iron hydride followed by a hydrogen atom transfer to an alkene, a coupling with a hydrazone, and a final reduction of the nitrogen-centered radical. Hydrogenation of the obtained hydrazines renders amines, including valuable tert-alkyl amines
%U https://pubs.acs.org/doi/10.1021/acscatal.8b03794