%0 Journal Article
%T Asymmetric Decarboxylative Cycloaddition of Vinylethylene Carbonates with ¦Â-Nitroolefins by Cooperative Catalysis of Palladium Complex and Squaramide
%J -
%D 2018
%R https://doi.org/10.1021/acscatal.8b03582
%X An efficient method for the enantio- and diastereoselective construction of multisubstituted tetrahydrofurans via asymmetric decarboxylative cycloaddition of vinylethylene carbonates with ¦Â-nitroolefins under a cooperative catalysis of palladium complex and squaramide is developed. By using a palladium complex generated in situ from Pd2(dba)3¡¤CHCl3 and phosphoramidite L1 and chiral squaramide OC4 as cooperative catalysts under mild conditions, the process provided multisubstituted tetrahydrofurans bearing a quaternary stereocenter in good to high yields with acceptably high enantio- and diastereoselectivities
%U https://pubs.acs.org/doi/10.1021/acscatal.8b03582