%0 Journal Article
%T Versatile Hyperbranched Poly(¦Â-hydrazide ester) Macromers as Injectable Antioxidative Hydrogels
%J -
%D 2018
%R https://doi.org/10.1021/acsami.8b15006
%X Synthetic reactive oxygen species (ROS)-responsive biomaterials have emerged as a useful platform for regulating critical aspects of ROS-induced pathologies and can improve such hostile microenvironments. Here, we report a series of new hyperbranched poly(¦Â-hydrazide ester) macromers (HB-PBHEs) with disulfide moieties synthesized via an ¡°A2 + B4¡± Michael addition approach. The three-dimensional structure of HB-PBHEs with multiacrylate end groups endows the macromers with rapid gelation capabilities to form (1) injectable hydrogels via cross-linking with thiolated hyaluronic acid and (2) robust UV-cross-linked hydrogels. The disulfide-containing macromers and hydrogels exhibit H2O2-responsive degradation compared with the counterparts synthesized by a dihydrazide monomer without disulfide moieties. The cell viability under a high ROS environment can be well-maintained under the protection of the disulfide containing hydrogels
%U https://pubs.acs.org/doi/10.1021/acsami.8b15006