%0 Journal Article
%T Non-Fickian Molecular Transport in Protein¨CDNA Droplets
%J -
%D 2018
%R https://doi.org/10.1021/acsmacrolett.8b00565
%X High Resolution Image Download MS PowerPoint Slide Bulk-level measurements of dynamics have suggested that phase-separated, protein¨Cnucleic acid rich droplets can be viewed as simple liquids. In this report, we show that histone proteins spontaneously phase separate into liquid-like droplets in the presence of DNA. Using super-resolution fluorescence microscopy, we find that molecular transport in these droplets is non-Fickian (subdiffusive) at nanoscopic length scales. This observation cannot be explained by charge¨Ccharge interactions. Instead, our results strongly suggest that cation£¿¦Ð interactions drive the non-Fickian behavior. Given the ubiquity of cationic and aromatic moieties in protein¨Cnucleic acid rich liquid-like phases observed in cells, we anticipate that non-Fickian diffusion is a general transport mechanism in such phases
%U https://pubs.acs.org/doi/10.1021/acsmacrolett.8b00565