%0 Journal Article
%T Biologically Active Branched Polysaccharide Mimetics: Synthesis via Ring-Opening Polymerization of a Maltose-Based ¦Â-Lactam
%J -
%D 2018
%R https://doi.org/10.1021/acsmacrolett.8b00302
%X Stereoregular poly-amido-saccharides bearing ¦Á-glucopyranose branches (Mal-PASs) are synthesized by anionic ring-opening polymerization of a maltose-based ¦Â-lactam monomer followed by debenzylation. The polymerization affords high molecular weight polymers (up to 31500 g/mol) with narrow dispersities (£¿ < 1.1). Deprotected Mal-PASs are highly soluble in water and adopt a left-handed helical conformation in solution. Turbidimetric assay shows that Mal-PASs are multivalent ligands to lectin Concanavalin A
%U https://pubs.acs.org/doi/10.1021/acsmacrolett.8b00302