%0 Journal Article
%T [email protected] Well-Designed Quercetin Delivery System for Chemo每Photothermal Therapy
%J -
%D 2018
%R https://doi.org/10.1021/acsami.8b13487
%X Quercetin (QT) is one promising candidate for the treatment of various cancers with virtually no toxic side effects. However, its anticancer effect is severely restricted by its poor bioavailability, low water solubility, and chemical instability in the neutral and alkaline medium. Herein, zeolitic imidazolate framework-8 (ZIF-8) is first reported as the multifunctional nanoplatform to the codelivery of quercetin as an anticancer agent and CuS nanoparticles as a photothermal therapy (PTT) agent for synergistic combination of chemotherapy and PTT as well as overcoming the drawbacks of quercetin. Moreover, folic acid每bovine serum albumin (FA每BSA) conjugates are applied to stabilize the [email protected] to promote the bioavailability of quercetin and realize active-targeting drug delivery. Near-infrared (NIR) fluorescent imaging demonstrated the highly increased drug accumulations of FA每BSA/[email protected] in tumors, resulting from efficient internalization via FA-receptors-mediated endocytosis. The results of in vivo and in vitro anticancer experiments demonstrate that quercetin and PTT agent can work together efficiently under NIR irradiation, thus remarkably improving the anticancer effect. Therefore, our newly designed FA每BSA/[email protected] multifunctional drug delivery system might be a promising nanoplatform for cancer treatment
%U https://pubs.acs.org/doi/10.1021/acsami.8b13487