%0 Journal Article
%T Preparation and Characterization of Acid Resistant Double Cross-Linked Hydrogel for Potential Biomedical Applications
%J -
%D 2018
%R https://doi.org/10.1021/acsbiomaterials.7b00818
%X A novel biocompatible polysaccharide-based hydrogel with double cross-linked network (DN) was designed and developed by combining dynamic imine bond and Diels¨CAlder (DA) click reaction. Our results showed that the dynamic covalent imine bond led to the hydrogel¡¯s self-healing property, while the DA reaction gave the superior thermodynamic property and acid resistance to the hydrogel. At the same time, the double cross-linked structure improved the mechanical properties of hydrogels. Moreover, the DN hydrogel had good biocompatibility, as confirmed by three-dimensional cell encapsulation. On the basis of these excellent properties, the present prepared hydrogel holds great potential in the field of biomaterials
%U https://pubs.acs.org/doi/10.1021/acsbiomaterials.7b00818