%0 Journal Article
%T Novel N每Br Bond-Containing N-Halamine Nanofibers with Antibacterial Activities
%J -
%D 2018
%R https://doi.org/10.1021/acsbiomaterials.7b00996
%X N-Halamine compounds have attracted great attention because they are recognized as promising antibacterial agents to control microbial contamination; however, most of the research interests were focused on N-halamines that contain N每Cl bond(s) rather than N每Br bond(s). In this contribution, we report the facile fabrication of N每Br bond-containing N-halamine nanofibers using the electrospinning method for antibacterial usages. The as-produced N每Br bond-containing N-halamine nanofibers (i.e., DBDMH/PAN nanofibers) comprise an antibacterial component of 1,3-dibromo-5,5-dimethylhydantoin (DBDMH) and a support component of polyacrylonitrile (PAN). When systematic characterizations were carried out, the as-obtained DBDMH/PAN nanofibers were proven to exhibit well-defined fiber-like morphology and be highly efficient in the killing of the selected model bacteria (Escherichia coli). Their morphology and size could be well governed by tuning the concentration of electrospinning precursor and the mass ratio of PAN to DBDMH. The antibacterial mechanism of the DBDMH/PAN nanofibers and their stabilities under dry, wet, and bacterial conditions were confirmed as well. Facile synthesis and antibacterial activity allow the feasibility of the final N每Br bond-containing N-halamine nanofibers for antibacterial-related clinical applications in practice. Our work highlights the development of the N每Br bond-containing N-halamine nanofibers as promising antibacterial agents for biomedical applications
%U https://pubs.acs.org/doi/10.1021/acsbiomaterials.7b00996