%0 Journal Article
%T Intracellular ROS Induction by [email protected] Core¨CShell Nanoparticles: Frontiers of Permanent Optically Active Holes in Breast Cancer Theranostic
%J -
%D 2018
%R https://doi.org/10.1021/acsami.8b03822
%X In this study, we investigated whether ZnO coating on Ag nanoparticles (NPs) tunes electron flux and hole figuration at the metal¨Csemiconductor interface under UV radiation. This effect triggers the photoactivity and generation of reactive oxygen species from [email protected] NPs, which results in enhanced cytotoxic effects and apoptotic cell death in human breast cancer cells (MDA-MB231). In this context, upregulation of apoptotic cascade proteins (i.e., Bax/Bcl2 association, p53, cytochrome c, and caspase-3) along with activation of oxidative stress proteins suggested the occurrence of apoptosis by [email protected] NPs in cancer cells through the mitochondrial pathway. Also, preincubation of breast cancer cells with [email protected] NPs in dark conditions muted NP-related toxic effects and consequent apoptotic fate, highlighting biocompatible properties of unexcited [email protected] NPs. Furthermore, the diagnostic efficacy of [email protected] NPs as computed tomography (CT)/optical nanoprobes was investigated. Results confirmed the efficacy of the photoactivated system in obtaining desirable outcomes from CT/optical imaging, which represents novel theranostic NPs for simultaneous imaging and treatment of cancer
%U https://pubs.acs.org/doi/10.1021/acsami.8b03822