%0 Journal Article
%T Construction of Vicinal All-Carbon Quaternary Stereocenters Enabled by a Catalytic Asymmetric Dearomatization Reaction of ¦Â-Naphthols with 3-Bromooxindoles
%J -
%D 2018
%R https://doi.org/10.1021/acscatal.8b03905
%X The organocatalyzed asymmetric dearomative addition of phenols to indol-2-ones generated in situ from 3-bromooxindoles was reported. This methodology leads to the efficient construction of a series of enantioenriched 3,3¡ä-disubstituted oxindoles bearing vicinal all-carbon quaternary stereocenters via a dearomatization process of phenols under mild reaction conditions. Additionally, the representative large-scale reactions and related transformations of the dearomatized products reveal the potential synthetic utility of this protocol
%U https://pubs.acs.org/doi/10.1021/acscatal.8b03905