%0 Journal Article
%T Self-Quenched Metal每Organic Particles as Dual-Mode Therapeutic Agents for Photoacoustic Imaging-Guided Second Near-Infrared Window Photochemotherapy
%J -
%D 2018
%R https://doi.org/10.1021/acsami.8b08419
%X The nanosized metal每organic particles (NMOPs) recently have attracted tremendous attentions in biomedical applications. However, few studies have developed metal每organic nanoparticles (NMOPs) as near-infrared (NIR) II phototherapeutic agents and as Fenton-like agents for cancer theranostics. Herein, directly using organic dye and Cu(II)-ion complexes to construct NMOPs, as dual-mode therapeutic agent for PA imaging-guided photochemotherapy in NIR II window, is reported. The NMOPs are simply an assembly of Cu(II) ion and tetrahydroxyanthraquinone (THQ) complexes [Cu(II)每THQ]n through the coordination effect, van der Waals force, and 羽每羽 interactions. After modification of polyethylene glycol (PEG每(NH2)2), the obtained Cu每THQNPs endow excellent biocompatibility and stability in physiological conditions. Because of the strong absorption at NIR II window and photoinduced electrontransfer (PET) mechanism, the Cu每THQNPs not only acted as an excellent photothermal agent with extremely high light-to-heat conversion ability (51.34%) at 1064 nm for phototherapy but also explored as the PA contrast agent for precisely tracking and guiding the therapy in vivo. Most strikingly, our Cu每THQNPs can be degraded by tumor-specific acidic-cleaving of the coordination bonds and follow by the slow release of Cu(II) into tumors, which can act as Fenton-like agents to generate ˋOH from H2O2 for enhancing the antitumor efficacy in vivo. With almost 100% prevention of the tumor growth for ca. 14 days and no obvious toxicity based on blood biochemical/histological analysis, this work highlights the Cu每THQNPs as an efficient NIR II therapeutic agent for precise cancer theranostics
%U https://pubs.acs.org/doi/10.1021/acsami.8b08419