%0 Journal Article
%T Potentially Important Therapeutic Interactions between Antibiotics, and a Specially Engineered Emulsion Drug Vehicle Containing Krill-Oil-Based Phospholipids and Omega-3 Fatty Acids
%A David F. Driscoll
%J Antibiotics | An Open Access Journal from MDPI
%D 2018
%R https://doi.org/10.3390/antibiotics7010022
%X Abstract The incidence of antimicrobial resistance (AMR) worldwide is increasing as the pipeline for the development of new chemotherapeutic entities is decreasing. Clearly, overexposure to antibiotics, including excessive dosing, is a key factor that fuels AMR. In fact, most of the new antibacterial agents under development are derivatives of existing classes of antibiotics. Novel approaches involving unique antimicrobial combinations, targets, and/or delivery systems are under intense investigation. An innovative combination of active pharmaceutical ingredients (APIs) consisting of antimicrobial drug(s), krill-oil-based phospholipids, and omega-3 fatty acid triglycerides, that may extend the therapeutic viability of currently effective antibiotics, at least until new chemical entities are introduced, is described. View Full-Tex
%K ¦Â-lactam antibiotics
%K ¦Â-lactamase inhibitors
%K krill oil phospholipids
%K omega-3 fatty acid triglycerides
%K antimicrobial resistance
%U https://www.mdpi.com/2079-6382/7/1/22