%0 Journal Article
%T Composite Wound Dressing Based on Chitin/Chitosan Nanofibers: Processing and Biomedical Applications
%A Anton S. Shabunin
%A Elena M. Ivan¡¯kova
%A Evgeny V. Zinovyev
%A Irina P. Dobrovolskaya
%A Pierfrancesco Morganti
%A Viktor Zubov
%A Vladimir E. Yudin
%J -
%D 2019
%R https://doi.org/10.3390/cosmetics6010016
%X Abstract An electrospinning technique was used for the preparation of a bilayered wound dressing consisting of a layer of aliphatic copolyamide nanofibers and a layer of composite nanofibers from chitosan and chitin nanofibrils filler. Processed dressings were compared with aliphatic copolyamide nanofiber-based wound dressings and control groups. Experimental studies (in vivo treatment of third-degree burns with this dressing) demonstrated that almost complete (up to 97.8%) epithelialization of the wound surface had been achieved within 28 days. Planimetric assessment demonstrated a significant acceleration of the wound healing process. Histological analysis of scar tissue indicated the presence of a significant number of microvessels and a low number of infiltrate cells. In the target group, there were no deaths or purulent complications, whereas in the control group these occurred in 25% and 59.7% of cases, respectively¡ªand, in the copolyamide group, 0% and 11%, respectively. The obtained data show the high efficiency of application of the developed composite chitosan£¿copolyamide wound dressings for the treatment of burn wounds. View Full-Tex
%K aliphatic copolyamide
%K chitosan
%K chitin nanofibrils
%K electrospinning
%K wound dressing
%K composite nanofibers
%K burns
%U https://www.mdpi.com/2079-9284/6/1/16