%0 Journal Article
%T The Role of Vitamin D in the Pathogenesis of Inflammatory Bowel Disease
%A Helen M. Pappa
%A Michela A. Tenace
%A Stefano Nobile
%J -
%D 2019
%R https://doi.org/10.3390/gidisord1010018
%X Abstract Vitamin D has a complex role in the pathogenesis of inflammatory bowel disease (IBD), which is still under investigation. We conducted a literature search using PubMed through December 2018 through the use of relevant search terms. We found an abundance of evidence to support the role of vitamin D in regulating the innate and adaptive arms of the immune system. The pathogenesis of IBD implicates the immune dysregulation of these immune system components. Proof of concept of the vitaminĄ¯s role in the pathogenesis of IBD is the mapping of the vitamin D receptor in a region of chromosome 12, where IBD is also mapped, and specific VDR polymorphismsĄ¯ link to IBD phenotypes. Further research is needed to better delineate vitamin DĄ¯s role in preventing IBD and its potential as a therapeutic target for this disease. View Full-Tex
%K vitamin D
%K inflammatory bowel disease
%K pathogenesis
%K immune system
%U https://www.mdpi.com/2624-5647/1/1/18