%0 Journal Article
%T Successful Amplified-Natural-Killer Cell (ANK) Therapy Administered to a Patient with Smoldering Adult T-Cell Leukemia in Acute Crisis
%A Gaowa Bai
%A Haorile Chagan-Yasutan
%A Keisuke Teshigawara
%A Sho Nagai
%A Toshio Hattori
%A Yuji Okubo
%J -
%D 2018
%R https://doi.org/10.3390/reports1020013
%X Abstract Adult T-cell leukemia (ATL) is an indolent leukemia caused by type 1 human T-cell leukemia virus (HTLV-1). A variety of therapeutic interventions via immunological approaches have been attempted. ATL cells express costimulatory molecules of natural killer (NK) cells, and a new modality¡ªamplified NK (ANK) cell treatment¡ªwas administered here to a patient with ATL. A 70-year-old female presenting with ringworm infection received a diagnosis of smoldering ATL in 2004. Monitoring of soluble IL-2 receptors (sIL-2Rs) in the serum showed disease exacerbation in 2007, associated with the enlargement of lymph nodes and formation of a skin tumor. NK cells were amplified by in vitro cell culture methods. To avoid cytokine release syndrome, 2¨C5 ¡Á 10 8 cells were administered with each injection. A total of 15 injections from 12 November 2007 to 15 February 2008 were administered to this patient. This case showed drastic downregulation of sIL-2R, resulting in the induction of complete remission, which lasted for >5 years. This is the first report of treatment of a patient with ATL using ANK cell therapy. More attempts of this therapy will enhance our insight into the appropriate application of this new therapy to clinically diverse patients. View Full-Tex
%K ATL
%K CD3
%K T cell receptor
%K HTLV-1
%K NK cells
%K therapy
%U https://www.mdpi.com/2571-841X/1/2/13