%0 Journal Article
%T Wingless/Wnt Signaling in Intestinal Development, Homeostasis, Regeneration and Tumorigenesis: A Drosophila Perspective
%A Ai Tian
%A Hassina Benchabane
%A Yashi Ahmed
%J -
%D 2018
%R https://doi.org/10.3390/jdb6020008
%X Abstract In mammals, the Wnt/¦Â-catenin signal transduction pathway regulates intestinal stem cell maintenance and proliferation, whereas Wnt pathway hyperactivation, resulting primarily from the inactivation of the tumor suppressor Adenomatous polyposis coli (APC), triggers the development of the vast majority of colorectal cancers. The Drosophila adult gut has recently emerged as a powerful model to elucidate the mechanisms by which Wingless/Wnt signaling regulates intestinal development, homeostasis, regeneration, and tumorigenesis. Herein, we review recent insights on the roles of Wnt signaling in Drosophila intestinal physiology and pathology. View Full-Tex
%K Wnt/Wingless signaling
%K Drosophila gut
%K animal model
%K intestinal physiology and pathology
%K Adenomatous polyposis coli (APC)
%K colorectal cancer
%U https://www.mdpi.com/2221-3759/6/2/8