%0 Journal Article
%T Skin Penetration and Stability Enhancement of Celastrus paniculatus Seed Oil by 2-Hydroxypropyl-¦Â-Cyclodextrin Inclusion Complex for Cosmeceutical Applications
%A Chiranan Khantham
%A Jakkapan Sirithunyalug
%A Krot Leksomboon
%A Pensak Jantrawut
%A Warintorn Ruksiriwanich
%J -
%D 2018
%R https://doi.org/10.3390/scipharm86030033
%X Abstract This study aimed to encapsulate Celastrus paniculatus seed oil (CPSO) in 2-hydroxypropyl-¦Â-cyclodextrin (HP¦ÂCD) cavities and investigate their biological activity, physicochemical stability, and skin penetration by vertical Franz diffusion cells of the CPSO-HP¦ÂCD inclusion complex formulations. For biological activity studies¡ªincluding 2,2-diphenyl-1-picryhydrazyl radical (DPPH) scavenging, metal ion chelating, and inhibition of lipid and tyrosinase inhibition activities¡ªthe CPSO-HP¦ÂCD inclusion complex exhibited lower inhibition activity than free CPSO. CPSO-HP¦ÂCD dispersion, serum, and gel formulations were prepared. All formulations containing the CPSO-HP¦ÂCD inclusion complex showed no significant changes in physical characteristics after three months¡¯ storage. The percentages of oleic acid remaining in all formulations were over 80% of the initial amount during a three-month stability study. For the skin-penetration study, compared to other formulations, the CPSO-HP¦ÂCD serum formulation exhibited the highest cumulative amount of oleic acid in the whole skin and flux through receptor fluid, after six hours, of 32.75 ¡À 1.25 ¦Ìg/cm 2 and 1.02 ¡À 0.15 ¦Ìg/cm 2/h, respectively. The CPSO-HP¦ÂCD serum formulation also showed the proper viscosity. Hence, the CPSO-HP¦ÂCD inclusion complex will be beneficial for the further development of cosmeceutical products. View Full-Tex
%K Celastrus paniculatus seed oil
%K cosmeceutical
%K 2-hydroxypropyl-¦Â-cyclodextrin inclusion complex
%K skin penetration
%K stability
%U https://www.mdpi.com/2218-0532/86/3/33