%0 Journal Article
%T First Description of Colistin and Tigecycline-Resistant Acinetobacter baumannii Producing KPC-3 Carbapenemase in Portugal
%A Aida Duarte
%A C¨¢tia Caneiras
%A Filipa Calisto
%A Gabriela Jorge da Silva
%A Jos¨¦ Melo-Cristino
%A Luis Lito
%J Antibiotics | An Open Access Journal from MDPI
%D 2018
%R https://doi.org/10.3390/antibiotics7040096
%X Abstract Herein, we describe a case report of carbapenem-resistant Acinetobacter baumannii and Klebsiella pneumoniae isolates that were identified from the same patient at a Tertiary University Hospital Centre in Portugal. Antimicrobial susceptibility and the molecular characterization of resistance and virulence determinants were performed. PCR screening identified the presence of the resistance genes bla KPC-3, bla TEM-1 and bla SHV-1 in both isolates. The KPC-3 K. pneumoniae isolate belonged to the ST-14 high risk clone and accumulated an uncommon resistance and virulence profile additional to a horizontal dissemination capacity. In conclusion, the molecular screening led to the first identification of the A. baumannii KPC-3 producer in Portugal with a full antimicrobial resistance profile including tigecycline and colistin. View Full-Tex
%K antimicrobial resistance
%K Gram-negative bacteria
%K K. pneumoniae
%K A. baumannii
%K KPC-3 carbapenemase
%K colistin
%K tigecycline
%U https://www.mdpi.com/2079-6382/7/4/96