%0 Journal Article
%T Extended and Fully Automated Newborn Screening Method for Mass Spectrometry Detection
%A G£¿tz Schlotterbeck
%A Irene Wegner
%A Jana Rykl
%A Ralph Fingerhut
%A Stefan Gaugler
%A Tamara Von D£¿niken
%J -
%D 2018
%R https://doi.org/10.3390/ijns4010002
%X Abstract A new and fully automated newborn screening method for mass spectrometry was introduced in this paper. Pathological relevant amino acids, acylcarnitines, and certain steroids are detected within 4 min per sample. Each sample is treated in an automated and standardized workflow, where a mixture of deuterated internal standards is sprayed onto the sample before extraction. All compounds showed good linearity, and intra- and inter-day variation lies within the acceptance criteria (except for aspartic acid). The described workflow decreases analysis cost and labor while improving the sample traceability towards good laboratory practice. View Full-Tex
%K newborn screening (NBS)
%K dried blood spots (DBS)
%K automation
%U https://www.mdpi.com/2409-515X/4/1/2